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M9470009.TXT
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1994-07-02
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Document 0009
DOCN M9470009
TI Fine T-cell subsets in alcoholics as determined by the expression of
L-selectin, leukocyte common antigen, and beta-integrin.
DT 9409
AU Cook RT; Waldschmidt TJ; Ballas ZK; Cook BL; Booth BM; Stewart BC;
Garvey MJ; Department of Pathology, Veterans Affairs Medical Center,
Iowa; City, IA.
SO Alcohol Clin Exp Res. 1994 Feb;18(1):71-80. Unique Identifier : AIDSLINE
MED/94256602
AB Alcoholics admitted to the hospital solely for detoxication have been
studied by flow cytometry to evaluate changes in the surface markers of
peripheral blood leukocytes. As we have shown previously, such patients
have an elevated percentage of CD8hi lymphocytes that are HLA DR+; we
now demonstrate that they also have striking alterations in the
quantitative relationships of the fine T-cell subsets. Both CD4+ and
CD8hi lymphocytes have a sharply reduced percentage of the L-selectin+
CD45RA+ subset, increased percentages of the CD45RA- subsets, and
several other fine subset alterations. The fine subset profile suggests,
according to current correlations of phenotype and function, that both
CD4+ suppressor inducer and CD4-dependent CD8+ suppressor effector cells
are reduced, whereas other subsets, including CD8+ CTL or their
precursors, are increased in relative percentages. Some of the
phenotypic changes are reversible over the several days following
withdrawal. In other results, the percentage of CD8hi lymphocytes
epxressing CD11b (beta-integrin) is shown to be reciprocal with the
percentage expressing L-selectin both in normals and alcoholics.
However, the regression function of CD11b vs. L-selectin on CD8hi cells
is different for the alcoholics than for the normals, indicating an
abnormality in the regulation of the expression of these two adhesion
markers. Taken together, this abnormality of adhesion molecules and the
fine subset alterations previously described indicate widespread changes
in the peripheral lymphocytes of currently drinking alcoholics. These
changes suggest functional deficiencies that may include alterations of
lymphocyte traffic and other adhesion-dependent functions, and a shift
in the balance of regulatory interactions.
DE Adult Alcoholism/*IMMUNOLOGY/REHABILITATION Antigens, CD45/*ANALYSIS
Cell Adhesion Molecules/*ANALYSIS CD4-CD8 Ratio/DRUG EFFECTS Human
Integrins/*ANALYSIS Macrophage-1 Antigen/ANALYSIS Male Middle Age
Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. T-Lymphocyte
Subsets/*IMMUNOLOGY T-Lymphocytes, Cytotoxic/DRUG EFFECTS/IMMUNOLOGY
T-Lymphocytes, Regulatory/DRUG EFFECTS/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).